The TTE Verdict
Antidepressants in mild depression
The TTE Verdict
In mild depression, the effect of antidepressants is clinically irrelevant - improvements are mainly attributable to placebo response, natural recovery, or nonspecific effects.
More than half of all (roughly 5 million people) antidepressant prescriptions in England are for people with mild depression, for which they derive little or no benefit.
Savings to the health service from reducing these prescriptions would be at least £460 million and potentially as high as £1.3 billion.
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