Why Observational Studies shouldn’t be used to assess Respiratory Virus Interventions - Part 2

The Long Read

We have seen how past observational studies of the SARS-CoV-1 epidemic gave implausible effect estimates while randomised trials gave more conservative estimates. However, there are other reasons specific to respiratory viral transmission why observational designs should be used cautiously for informing policy.

Let’s try and put these in the context of t…