Trust the Evidence

Trust the Evidence

Why Respiratory Virus Hospital-acquired Infections Matter

RV HAI or RV HCAI are not background noise; they are a core driver of harm and system strain that policy must address.

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Tom Jefferson's avatar
Carl Heneghan and Tom Jefferson
Jan 06, 2026
∙ Paid

Hospital-acquired infections with respiratory viruses (RV HAIs) are a significant concern because they have serious clinical, public health, and economic consequences, particularly in healthcare settings where vulnerable populations are concentrated.

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Hospital patients often have weakened immune systems, chronic lung or heart disease or advanced age or frailty. Respiratory viruses can cause severe disease, complications such as pneumonia and respiratory failure, and even death in these groups.

RV HAIs are associated with longer hospital stays and higher ICU admission rates. In a cohort of 1,700 patients with RV HAI, patients had longer mean lengths of stay (e.g., 21 days vs. 5 days in community-acquired cases). These patients were older, had pre-existing respiratory disorders or were immunosuppressed and faced greater RV HAI risk. They were also likely to exhibit typical respiratory infection symptoms, which could delay diagnosis.

RV HAIs are also associated with significantly higher mor…

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